Wednesday, September 4, 2013

Article stem cell involvement in origin of endometriosis

"Endometriosis is a common gynecological disease. It is unique to have benign histology but

with malignant characteristics. Easy recurrence, multiple organ involvement and malignant

transformation potential make endometriosis a complex disease. Multi-factors contribute to

the pathophysiology. Recently, endometriosis has been regarded as a stem cell disease

(Sasson & Taylor, 2008). Some studies have provided evidence of the possible existence of

stem cells in endometrial tissue (Gargett et al., 2004, 2007). We successfully isolated eutopic

and ectopic endometrial mesenchymal stem cells (EN-MSCs) derived from one donor to

examine the genetic difference analysis that provided a powerful tool for investigating the

disease origin (Kao et al., 2011). Our results are consistent with the concept that

endometriosis is a stem cell disease."